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Metformin and dementia


Metformin, Type 2 Diabetes, and dementiaūü߆

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A new study shows that in older people with diabetes, metformin, a medication widely used to treat diabetes, delays cognitive deterioration, and decreases the risk of dementia.

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Previous studies have suggested that metformin can penetrate the blood-brain barrier, protecting neurons via anti-inflammatory action and improvement of brain energy metabolism. This fact led the scientist to test the effect of metformin on cognitive function in patients with abnormal glucose metabolism.

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ūüĒ¨A six-year study of older Australians (aged 70 to 90 years old at baseline), has revealed a link between metformin use, slower cognitive decline, and lower dementia rates.

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People living with type 2 diabetes have a staggering 60% risk of developing dementia. Individuals with type 2 diabetes taking metformin had a significantly slower cognitive decline and lower dementia risk compared to those not taking metformin.

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This observational study does not provide conclusive ‚Äėproof‚Äô that metformin is protective against dementia, but more research (randomized controlled trial) will help us to establish a definitive effect of metformin on dementia.

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Research study:

https://doi.org/10.2337/dc20-0892

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hpbrain.org

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