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Lithium and Alzheimer's disease

šŸ˜±Studies in rodents suggest that very low doses of lithium may help treat Alzheimerā€™s disease.


Scientist discovered that just a microdose of the compound called NP03 can halt the

progression of this neurodegenerative condition (even in advanced stage) in the rat model.


However, the lithium compound used in the studies wasnā€™t just regular lithium, it was encapsulated lithium designed to facilitate passage to the brain.


šŸ‘‰You may be asking yourself: ā€œWhat was the dose?ā€

šŸ‘‰Well, the dose was 400 times lower than what is currently being prescribed for people with mood disorders. Lithium carbonate, or lithium salt, is mainly used to treat and prevent bipolar disorder.


ā–ŖļøThat dose was able to halt the signs of advanced Alzheimerā€™s pathology (it reduced levels of amyloid plaques) and recover some cognitive abilities (like object recognition). Overall lithium compound reduced markers of neuroinflammation and oxidative stress.


ā–ŖļøOne study reported that people exposed to drinking water with higher concentrations of lithium were 17% less likely to develop dementia than people whose water contained barely

any lithium.


ā–ŖļøAlso, the systematic review and meta-analysis from 2015 (ā€œLithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysisā€) indicates that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD




NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology

in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats. Journal of Alzheimer's Disease,

2020; 73 (2): 723 DOI: 10.3233/JAD-190862


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