š±Studies in rodents suggest that very low doses of lithium may help treat Alzheimerās disease.
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Scientist discovered that just a microdose of the compound called NP03 can halt the
progression of this neurodegenerative condition (even in advanced stage) in the rat model.
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However, the lithium compound used in the studies wasnāt just regular lithium, it was encapsulated lithium designed to facilitate passage to the brain.
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šYou may be asking yourself: āWhat was the dose?ā
šWell, the dose was 400 times lower than what is currently being prescribed for people with mood disorders. Lithium carbonate, or lithium salt, is mainly used to treat and prevent bipolar disorder.
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āŖļøThat dose was able to halt the signs of advanced Alzheimerās pathology (it reduced levels of amyloid plaques) and recover some cognitive abilities (like object recognition). Overall lithium compound reduced markers of neuroinflammation and oxidative stress.
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āŖļøOne study reported that people exposed to drinking water with higher concentrations of lithium were 17% less likely to develop dementia than people whose water contained barely
any lithium.
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āŖļøAlso, the systematic review and meta-analysis from 2015 (āLithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysisā) indicates that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD
dementia.
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šReference:
NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology
in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats. Journal of Alzheimer's Disease,
2020; 73 (2): 723 DOI: 10.3233/JAD-190862
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